Oxidative Stress in Homocysteinemia: The Prevention of the Therapy-Induced Peripheral Neuropathy
نویسنده
چکیده
Oxidative stress (OS) is an unhealthy condition that results from the imbalance between the production of reactive oxygen species (ROS) and the rate of their elimination through the anti-oxidant defence mechanisms. This condition is a part of the pathogenesis of many disease conditions. In this paper, the development of OS in homocysteinemia is highlighted, where some light is shed on the mechanism of the increased ROS production and the potential protective strategy in the clinical practice.
منابع مشابه
Effects of Melatonin and Vitamin E on Peripheral Neuropathic Pain in Streptozotocin-Induced Diabetic Rats
Objective(s) Previous studies have indicated that diabetes mellitus might be accompanied by neuropathic pain. Oxidative stress is implicated as a final common pathway in development of diabetic neuropathy. Pharmacological interventions targeted at inhibiting free radical production have shown beneficial effects in diabetic neuropathy. The aim of this study was to investigate and compare the po...
متن کاملAnti-inflammatory and anti-apoptotic effects of hyperbaric oxygen preconditioning in a rat model of cisplatin-induced peripheral neuropathy
Objective(s): Cisplatin-induced peripheral neuropathy is a debilitating side effect in patients receiving this drug. Recent studies suggest hyperbaric oxygen (HBO) therapy as a new treatment approach for models of neural injury. The aim of the current study was to determine the protective effects of HBO preconditioning against peripheral neuropathy induced by Cisplati...
متن کاملتأثیر آتورواستاتین بر پاسخ استرس اکسیداتیو مغز و آسیب نورونی ناشی از دیابت
Background and Aim: Based on recent studies, atorvastatin has some pleiotropic actions such as anti-inflammatory and anti-oxidant effects independent of lipid lowering effects. Regarding the critical role of oxidative stress and inflammation in inducing diabetic neuropathy, the current study aimed at examining the neuroprotective and anti-oxidative stress effects of atorvastatin atthe brain tis...
متن کاملOxidative stress and nerve damage: Role in chemotherapy induced peripheral neuropathy☆
Peripheral neuropathy is a severe dose limiting toxicity associated with cancer chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) remain sparse and considerable involvement of oxidative stress and neuroinflammation has been realized recently. Despite the empirical use of antioxidants in the therapy of CIPN,...
متن کاملP155: The Role of Vegan Diet in Epilepsy
Food habits have a serious role in the emergence of the diseases and inflammation that causes many kinds of diseases. Some case-control studies concluded that high animal fat and cholesterol in diet is associated with some neuroinflammatory diseases such as Parkinson and Alzheimer. High level of cholesterol and lipopolysaccharides(LPS) include the peripheral inflammation in the body. There is e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017